Direct Activation of TRPC3 Channels by the Antimalarial Agent Artemisinin
(1) Background: Members of the TRPC3/TRPC6/TRPC7 subfamily of canonical transient receptor potential (TRP) channels share an amino acid similarity of more than 80% and can form heteromeric channel complexes.They are directly gated by diacylglycerols in a protein kinase C-independent manner.To assess TRPC3 channel functions without concomitant prote